Thursday, 02 May 2013
Plasmodium is transmitted to a mammalian host during the bite by an infected anopheline mosquito. The sporozoite form of the parasite is injected into the skin and eventually reaches the liver, where it invades a hepatocyte inside a vacuole and transforms into thousands of red blood cell-infective forms. To access the liver parenchyma and hepatocytes, the sporozoite thus needs to cross the liver sinusoidal barrier.
Wednesday, 01 May 2013
“Our survey of genetic variation showed that Western Cambodian malaria parasites had a population structure that was strikingly different to those of the other countries we analysed. Different not just from countries in Africa, but also different from malaria parasite populations in neighbouring Thailand, Vietnam, and even Eastern Cambodia,” says Professor Dominic Kwiatkowski, senior author of the paper from the Wellcome Trust Sanger Institute and University of Oxford.
Thursday, 25 April 2013
The blood stage of Plasmodium falciparum is responsible for the high morbidity and mortality associated with malaria. In this stage, P. falciparum merozoites invade red blood cells (RBC), replicate and exit from the host cell upon maturation. Released merozoites go on to reinvade uninfected RBCs and continue their life cycle. Egress of P. falciparum merozoites from mature schizonts requires the timely rupture of the host cell membrane through a highly regulated and active process.
Monday, 08 April 2013
This year for Red Nose Day, the EVIMalaR office teamed up with others in Glasgow University to help raise money for Comic Relief! This included a bake sale, a raffle and book donations. Our efforts helped raise £179.00 which contributed towards the £75,107,851 raised so far.
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