Malaria impairs resistance to Salmonella through heme- and heme oxygenase–dependent dysfunctional granulocyte mobilization

Aubrey J Cunnington, J Brian de Souza, Michael Walther & Eleanor M Riley

In sub-Saharan Africa, invasive nontyphoid Salmonella (NTS) infection is a common and often fatal complication of Plasmodium
falciparum infection. Induction of heme oxygenase-1 (HO-1) mediates tolerance to the cytotoxic effects of heme during malarial
hemolysis but might impair resistance to NTS by limiting production of bactericidal reactive oxygen species.

Read more

The CTLA-4 and PD-1/PD-L1 Inhibitory Pathways Independently Regulate Host Resistance to Plasmodium-induced Acute Immune Pathology.
Hafalla JC, Claser C, Couper KN, Grau GE, Renia L, de Souza JB, Riley EM.
PLoS Pathog. 2012 Feb;8(2):e1002504. Epub 2012 Feb 2.
PMID: 22319445 [PubMed - in process]

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division
Volz JC, Bártfai R, Petter M, Langer C, Josling GA, Tsuboi T, Schwach F, Baum J, Rayner JC, Stunnenberg HG, Duffy MF, Cowman AF.
Cell Host Microbe. 2012 Jan 19;11(1):7-18.
PMID: 22264509 [PubMed - in process]

Critical Role for Heat Shock Protein 20 (HSP20) in Migration of Malarial Sporozoites.
Montagna GN, Buscaglia CA, Munter S, Goosmann C, Frischknecht F, Brinkmann V, Matuschewski K.
J Biol Chem. 2011 Dec 2. [Epub ahead of print]
PMID: 22139844

A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle.
Angrisano F, Delves MJ, Sturm A, Mollard V, McFadden GI, Sinden RE, Baum J.
Mol Biochem Parasitol. 2011 Nov 25. [Epub ahead of print]
PMID: 22138565
Related citations